Sepsis

Sepsis or, more commonly, blood poisoning causes more deaths than prostate cancer, breast cancer, and AIDS combined. 30 million people get sepsis every year, and 20 people die from it every minute. Sepsis is the body’s extreme response to an infection. It happens when an infection you already have, for example in your lungs, triggers a chain reaction throughout your body.

Sepsis is life-threatening, and without timely treatment, it can cause organ failure and death.  Antimicrobial therapy is a key element in treatment – in septic shock, the initiation of antibiotic therapy within one hour increases survival; with each hour antibiotic therapy is delayed, survival decreases by about 8% (Kumar et al. Crit Care Med. 2006).


Slow diagnostics leads to an overuse of broad spectrum antibiotics

When blood samples are sent to microbiology labs for culturing, cultures that are positive for bacteria or fungi are subjected to antibiotic susceptibility testing (AST). If the infecting agent is resistant to an administered drug, the therapy can be changed to an effective antibiotic. However, the response time for these tests may be up to 72 hours, which is too long to affect treatment for the patient in question. It is not uncommon that the patient has either died or responded to the treatment and is in recovery when the test results are back. With a shortened response time for identification of the infecting agent as well as the antibiotic susceptibility testing, the usage of broad spectrum antibiotics could be reduced significantly.


 

Health economy effects of 24 h earlier AST results